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High prevalence of advanced liver fibrosis assessed by transient elastography among US adults with type 2 diabetes

Diabetes Care Dec 15, 2020

Ciardullo S, Monti T, Perseghin G., et al. - In US adults with type 2 diabetes mellitus (T2DM), researchers assessed the prevalence of steatosis and fibrosis on the basis of transient elastography (TE) and distinguished factors correlated with these conditions. Researchers designed a cross-sectional study of US adults with T2DM participating in the 2017–2018 cycle of the National Health and Nutrition Examination Survey who were assessed by TE. Researchers detected hepatic steatosis and fibrosis by the median value of the controlled attenuation parameter and liver stiffness measurement, respectively. In this study, 484 (53.7%) were evaluated applying the M probe and 341 (46.3%) using the XL probe among the 825 patients with reliable TE examination results. This study’s findings revealed that the prevalence of both liver steatosis and fibrosis is high in these patients with T2DM; obesity is a major risk factor. Liver steatosis was present in 73.8% of participants, advanced fibrosis was present in 15.4%, and cirrhosis was present in 7.7% of them. The outcomes support the screening of these conditions among patients with diabetes. In the multivariable logistic regression model, independent predictors of steatosis were BMI, non-Black race, and ALT levels; independent predictors of advanced fibrosis were and BMI, non-Black race, and AST and γ-glutamyltranspeptidase levels.

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