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High plasma microfibrillar-associated protein 4 is associated with reduced surgical repair in abdominal aortic aneurysms

Journal of Vascular Surgery Dec 05, 2019

Lindholt JS, Madsen M, Kirketerp-Møller KL, et al. - In this study, researchers investigated the potential value of plasma microfibrillar-associated protein 4 (pMFAP4) as a biomarker of abdominal aortic aneurysms (AAA). In the Viborg Vascular screening trial, 504 male AAA patients and 188 controls provided plasma samples. Using Alphalisa, they measured the pMFAP4 levels. Differences in pMFAP4 levels between the presence and absence of different exposures of interest were assessed via the Mann-Whitney U test. Spearman correlation analysis was done for investigating the correlation between pMFAP4 and aorta growth rate. Findings suggested an association of high levels of pMFAP4 with a reduced likelihood of receiving surgical repair in AAA.
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