Strong EA, Park SH, Ethun CG, et al. - As there are no well-validated biomarkers for soft tissue sarcomas, researchers sought to elucidate the impact of circulating neutrophil-lymphocyte ratio in soft tissue sarcomas. In this retrospective analysis of patients undergoing curative resection for primary or recurrent extremity soft tissue sarcomas at academic centers within the US Sarcoma Collaborative, they observed independent value of increasing age, American Joint Committee on Cancer T3, American Joint Committee on Cancer T4, high tumor grade, and radiotherapy, but not of a high neutrophil-lymphocyte ratio, for predicting survival. This suggests no independent correlation of tumor inflammation, as measured by high pretreatment neutrophil-lymphocyte ratio, with overall survival in patients undergoing resection for extremity soft tissue sarcomas.