Shinkai N, et al. - Researchers analyzed the role of serum Mac-2-binding protein glycosylation isomer (M2BPGi) in determining the development of hepatocellular carcinoma among hepatitis B patients. Higher M2BPGi at 48 weeks, as well as male sex and higher alpha-fetoprotein (AFP) at 48 weeks, were independent risk factors for hepatocellular carcinoma (HCC) development in patients receiving nucleot(s)ide analogues (NA) therapy.