Li Q, Wang Y, Xu L, et al. - Researchers performed bioinformatic analysis to determine the CD10 (a common zinc-dependent metalloid protease) expression in head and neck squamous cell carcinoma (HNSCC) as well as its link with tumour prognosis. They also investigated whether a CD10-driven signalling pathway showed potential in a tumour-immune microenvironment. Briefly, in data mining analysis, HNSCC patients exhibited a strengthened CD10 expression. Unfavourable overall survival and recurrence-free survival were noted in relation to high CD10 expression. The poor prognosis of HNSCC could potentially be explained by the correlation between CD10 expression and interleukin ( IL) -6/IL-8-mediated M1 macrophage activity. Of 692 genes co-expressed with CD10 in HNSCC, the following were identified as the candidate signalling pathways driven by the CD10 gene: Rap1 signalling pathway, regulation of actin cytoskeleton, protein digestion and absorption, proteoglycans in cancer, PI3K-Akt signalling pathway, focal adhesion and extracellular matrix–receptor interaction. To better the prognosis of HNSCC patients by immunotherapy, further inquiry of immune-related signalling pathways regulated by CD10 may be useful.