Abrahamsson H, et al. - Given that a dominant metastatic progression is still reported following curative-intent neoadjuvant therapy in locally advanced rectal cancer, researchers examined the link between patients’ circulating 25-hydroxyvitamin D [25(OH)D] levels and outcome in this post hoc analysis. From 84 patients, they obtained samples and evaluated serum 25(OH)D level via liquid chromatography-mass spectrometry at baseline, at the end of neoadjuvant therapy, and treatment assessment prior to surgery. They analyzed serum 25(OH)D level by season, disease presentation, and treatment impacts. A high risk of metastatic progression and mortality was reported in relation to inadequate circulating 25(OH)D levels in rectal cancer T4 cases, but these patients vs patients with T2-3 disease had no worse short-term and long-term outcome to neoadjuvant therapy when 25(OH)D was adequate.