Meester RGS, et al. - US individuals aged 50, 60, or 70 years with low-risk adenomas (1 to 2 small adenomas) or high-risk adenomas (3 to 10 small adenomas or ≥ 1 large adenoma) removed following the screening with colonoscopy or fecal immunochemical testing were included to contrast the lifetime advantages and costs of high- vs low-intensity surveillance. For adenoma recurrence, colorectal cancer incidence, longevity, quality of life, screening ages, surveillance ages, test performance, disutilities, and cost, the cost of high-intensity surveillance was less than $100,000 per QALY attained in most alternative situations. Thus, the microsimulation model suggests that high-intensity surveillance as suggested in the United States gives moderate yet clinically appropriate advantages over low-intensity surveillance at an agreeable cost.