Maleki BH, et al. - Infertile men (n = 441) were randomly allotted to exercise (EX, n = 221) or non-exercise (NON-EX, n = 220) group in order to examine the influences of 24 weeks of high-intensity interval training (HIIT) on markers of male reproductive function in infertile males. The intervention led to reduced seminal levels of proinflammatory cytokines (IL-1β, IL-6, IL-8, and TNF-α) and markers of oxidative stress (ROS, MDA, and 8-isoprostane). With HIIT intervention, the concentrations of seminal antioxidants were unchanged. These modifications additionally corresponded with encouraging advancements in semen parameters, sperm DNA integrity and rates of pregnancy. This could symbolize that through reduced oxidative damage and proinflammatory status, HIIT provoked advantageous influences on markers of male reproductive function. Therefore, findings reflect the likelihood that for male factor infertility, HIIT could be an efficient intervention and support they require for additional human studies.