Boehnke KF, et al. - Researchers conducted a cross-sectional survey to investigate if daily cannabis use frequency influences pain severity and interference, quality of life measures relevant to pain (eg, anxiety and depressive symptoms), and cannabis use preferences (administration routes, cannabinoid ratio). They included 989 participants and designated cannabis use as light, moderate, and heavy (1-2, 3-4, and 5 or more cannabis use per day, respectively). Sub-grouping of the sample was performed by self-reported medical only use (designated MED, n = 531, 54%) vs medical use concomitant with a past-year history of recreational use (designated MEDREC, n = 458, 46%). In the whole sample, greater daily frequency of cannabis use was significantly associated with higher pain severity. Heavy MED participant consumption patterns were observed in correlation with smoking, vaporizing, and high levels of THC. In contrast, light MED participants had greater liking for tinctures and high CBD products. Findings thereby imply that MED participants have a better clinical profile as well as lower risk cannabis use behaviors in correlation with lower daily cannabis use frequency.