Vourc'h M, et al. - In this randomized, single-center, open-labeled, controlled trial, researchers ascertained if high-flow oxygen therapy by nasal cannulae (HFNC) was more effective than a high-flow face mask (HFFM) in severe hypoxemia. Participants in the study were cardiac surgery patients presenting oxygen saturation <96% with Venturi mask 50%. Data reported that the co-primary outcomes were the PaO₂/F_IO₂ ratio at 1 and 24 hours. Compared to HFFM, the HFNC improved satisfaction and reduced mucus dryness. According to findings, PaO₂/F_IO₂ at 1 and 24 hours were higher and the use of noninvasive ventilation was reduced in HFNC vs HFFM in patients with severe hypoxemia after cardiac surgery.