Liu J, et al. - In order to comprehend the progression of lung adenocarcinoma (AC), researchers gauged the expression of Synthesis of cytochrome c oxidase 2 (SCO2) and TP53-induced glycolysis and apoptosis regulator (TIGAR) proteins in lung AC along with the potential relation to prognosis. A prominent link was discovered between high TIGAR expression with a history of smoking and being male, as well as between high SCO2 expression and age. Data demonstrate that the high expression of the SCO2 and TIGAR proteins predicted poorer survival and a higher mortality rate. Owing to the prominent connection between high expression of SCO2 and TIGAR proteins with lung AC progression, these served as potential prognostic markers and therapeutic targets.