Eckhardt C, Sbiera I, Krebs M, et al. - Researchers sought to assess whether Sterol-O-Acyl transferases (SOAT) 1 and 2 tissue expression have value as prognostic markers in high risk prostate cancer (PCa). This study involved 305 high risk PCa cases managed with radical prostatectomy. Experts found high and low expression of SOAT1 in 73 (25%) and 219 (75%; not evaluable: 13) tumors, respectively. A high expression of SOAT2 was evident in 40 (14%) and was at low levels in 249 (86%) samples (not evaluable: 16). According to Kaplan–Meier analysis, patients with high SOAT1 experienced a significantly shorter median biochemical recurrence (BCR) free survival of 93 months, vs 134 months with low SOAT1. There was absence of a significant link between SOAT2 expression and BCR. Overall, findings demonstrated a strong connection of SOAT1 expression with BCR free survival alone and after multivariable adjustment in high risk PCa. SOAT1 may not only be used as a histologic marker of prognosis but also holds promise as a future therapeutic target.