Wang DP, Zhao R, Qi YH, et al. - This study was sought to evaluate if interleukin-2 receptor subunit gamma (IL2RG) is a key molecule that can serve as a biomarker in human gastric cancer (GC) progression. During tumor radical excision surgery, GC tissues and paracancerous gastric tissues were collected from seven patients (five males and two females). RNA-seq and serial bioinformatics analyses, including Kyoto Encyclopedia of Genes and Genomes pathway analysis, gene expression profiling interactive analysis, and survival analysis were used to distinguish the differentially expressed genes in these tissues. In advanced GC, IL2RG is overexpressed and is correlated with low survival. Results showed striking elevations of IL2RG both in the mRNA and protein levels in GC tissues and human gastric cancer SGC-7901 cell line compared, respectively, with the adjacent normal gastric tissues and normal GES-1 cells. The small molecule, resatorvid (TAK 242), could be an inhibitor of IL2RG, as seen via molecular docking. The data demonstrate that IL2RG may serve as a biomarker of GC progression and poor prognosis.