Stenlid R, et al. - Given that dipeptidyl peptidase 4 (DPP-4) metabolizes glucagon-like peptide-1 (GLP-1), and increased DPP4 levels are linked to obesity and visceral adiposity in adults, researchers assessed DPP-4 levels in adolescents and their relationship with circulating intact GLP-1 levels and glucose tolerance; body mass index (BMI); and visceral, subcutaneous, and liver fat compartments. In this cross-sectional study, they examined children and adolescents with obesity (n=59) and lean controls (n=21) aged 8 to 18 years from July 2012 to April 2015. They found that adolescents had high plasma DPP-4 concentrations that were related to low proportions of intact GLP-1, high BMI, young age, and male sex. The observed associations were found to be compatible with increased metabolism of GLP-1 in childhood obesity.