Brustad N, et al. - Researchers intended to determine whether there is a link between high-dose supplementation of vitamin D during pregnancy and asthma in offspring at age 6. Due to the difficulty of diagnosing asthma early in life, they followed the children at the age of 6 to evaluate the risk of current asthma. The Copenhagen Prospective Studies on Asthma in Childhood 2010 vitamin D randomized clinical trial (RCT) found that children of women randomized to high-dose compared to standard-dose vitamin D at 3 years of age did not have a statistically significant reduced risk of persistent wheeze. However, it was not possible to exclude a clinically important protective effect. The study findings suggested that low in utero vitamin D levels could be related to risk of asthma in offspring.