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High dose ibuprofen as a monotherapy on an around-the-clock basis fails to control pain in children undergoing tonsil surgery: A prospective observational cohort study

European Archives of Oto-Rhino-Laryngology Apr 10, 2020

Gude P, Gustedt F, Bellgardt M, et al. - Given a possible efficacy of ibuprofen on an “around-the-clock” basis to control postoperative pain sufficiently in children after tonsil surgery, researchers established a standard scheme with weight-adapted recommended maximum ibuprofen dose. The Children’s and Infants’ Postoperative Pain Scale (CHIPPS) and the Faces Pain Scale-Revised (FPS-R) are reliable tools for assessing pain intensity in children < 5 years and in children aged ≥ 5 years, respectively. For both age groups, the Parents’ Postoperative Pain Measure (PPPM-D) may be a useful tool. In this work, they tested their hypothesis that an opioid rescue medication would be required in not more than 30% of the children during their in-hospital stay and examined the consistency of the PPPM-D with other pain scales. Ibuprofen was orally administered every 8 h to 158 in-patients aged 2–12 years. Outcomes revealed insufficiency of high-dose ibuprofen “around-the-clock” to control pain in these children after tonsil surgery. In the PPPM-D, the cut-off value for relevant pain was mostly exceeded, but it was identified to had an overall low concordance to the reference scales.

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