Allaire J, et al. - In a double-blind, controlled, crossover study, researchers investigated the phenotypic change in low-density lipoprotein (LDL) and mechanisms responsible for the differential low-density lipoprotein cholesterol (LDL-C) response to eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supplementation in men and women at risk for cardiovascular disease. In this investigation, 48 men and 106 women with abdominal obesity and subclinical inflammation were randomized to a sequence of 3 treatment phases: phase 1, 2.7 g/d of EPA; phase 2, 2.7 g/d of DHA; and phase 3, 3 g/d of corn oil. Data revealed that high-dose DHA supplementation increases LDL turnover and contributes to larger LDL particles vs EPA.