Icks A, Wittgens C, Haastert B, et al. - This study was attempted to ascertain the 10-year cumulative incidence of high depressive symptoms in people with diagnosed and, in particular, previously undetected diabetes compared to those without diabetes in a population-based cohort study in Germany. Researchers enrolled 2,813 participants (52.9% men, mean age (SD) 58.9 (7.7) years, 7.1% diagnosed diabetes, 5.6% previously undetected diabetes) from the Heinz Nixdorf Recall study. The odds ratios with 95% confidence intervals were estimated using multiple logistic regression analyses for diagnosed and undetected diabetes. An increased odds of developing high depressive symptoms was observed in participants with diagnosed diabetes. Nevertheless, the odds ratios decreased when we considered comorbidities and other covariates.The odds were not increased, even 10 years after detection of diabetes in participants with previously undetected diabetes. These outcomes demonstrate the hypothesis that high depressive symptoms develop due to diabetes-related burdens and comorbidities and not due to hyperglycemia or hyperinsulinemia.