Huang Q, et al. - In the observational cohort study, researchers investigated whether high-desity lipoprotein (HDL) levels are associated with growth and rupture of intracranial aneurysms. They analyzed data obtained from 581 patients with intracranial aneurysms regarding age, sex, admission systolic blood pressure (SBP), history of diabetes and hypertension, history of coronary artery disease, aneurysmal rupture, apolipoprotein-A1 (APO-A1), apolipoprotein-B (APO-B), HDL, low-desity lipoprotein (LDL), triglyceride, cholesterol, aneurysm location, and aneurysm size. Findings suggested an inverse association of HDL with intracranial aneurysm growth, especially in male patients. High risk of aneurysmal rupture was evident with higher HDL levels and small size of aneurysm. A valuable predictor of intracranial rupture included the ratio of HDL and aneurysm size greater than 0.31.