Takeya H, et al. - In patients with esophageal cancer, researchers examined the relationship between CD169 expression in regional lymph nodes (RLNs) and clinicopathologic factors. In patients undergoing pretreatment, the density of tumor-infiltrating lymphocytes (TILs) in the cancer nest and CD169 expression in lymph node sinus macrophages (LySMs) were positively associated. The expression indoleamine 2,3-dioxygenase (IDO1) on LySMs was positively associated with the expression CD169, but there was no significant relationship between IDO1 and clinicopathological factors. Investigators found that high CD169 expression in LySMs reflects a high potential for anti-cancer immune responses in patients with esophageal cancer and that monitoring CD169 expression would be helpful in assessing the potential for anti-cancer immune reactions.