Leiherer A, Ebner J, Muendlein A, et al. - Researchers focused on the link of betatrophin (a nutritionally-regulated mammalian-specific protein secreted by the liver and adipose tissue) with cardiovascular risk using a study sample of 553 coronary patients undergoing coronary angiography for the assessment of confirmed or suspected stable coronary artery disease (CAD). Among participants, betatrophin was measured and a follow-up of up to 8 years was performed to prospectively document cardiovascular events. A cardiovascular event was experienced by 201 patients and 64 died due to cardiovascular causes during follow-up. They observed a significant as well as an inverse link of high betatrophin (upper tertile) with cardiovascular events both univariately and following complete adjustment including the status of CAD and T2D. Findings revealed that the prediction of cardiovascular events was enabled by betatrophin, independently of traditional risk factors including the presence of CAD and T2D, and this revelation happened for the first time ever in this study.