Dustler M, et al. - Using a novel artifact-reducing reconstruction algorithm in specimen radiography, researchers evaluated the impact on reducing the out-of-plane artifacts from metal objects in breast tomosynthesis (BT). BT images of 18 partial and whole mastectomy specimens were acquired from women with breast cancer before and after a needle was inserted near the lesion. Compared to BT-images without artifact reduction, the magnitude of out-of-plane artifacts was clearly decreased with the novel reconstruction. Signal-difference to background ratio (SDBR) increased by 97% in the phantom, and by 69% in the mastectomies with metal artifact reduction. Findings revealed that the artifact spread function was substantially narrower. Using a novel reconstruction method, artifact reduction in BT allows for qualitatively and quantitatively improved clinical use of BT when metal artifacts can be a limiting factor such as in tomosynthesis-guided biopsy.