Wang M, Li Y, Cong L, et al. - Via this population-based cross-sectional study, researchers attempted to explore a range of serum lipids in association with brain structure as well as cognitive function in rural-dwelling older adults. Participants were 184 rural-dwelling adults (age ≥65 years, 39.1% women) in Shandong, China. They found low HDL-C (<1.55 vs ≥1.55 mmol/L) was significantly related to decreased volumes of total white matter and hippocampus, a lower Mini-Mental State Examination score, and a higher probability of mild cognitive impairment. Thus, a possible involvement of low HDL-C in structural brain aging and cognitive dysfunction was indicated in this population, however, the link of low HDL-C with cognitive aging phenotypes seemed not to be mediated by brain structure.