Swartz JE, Wegner I, Noorlag R, et al. - Given that hypoxia is a negative prognostic factor in head and neck squamous cell carcinomas, experts aspired to explore whether there were site differences in hypoxia‐inducible factor (HIF)‐1a expression and its effect on patient outcomes per subsite. In total, 941 patients with HNSCC in the squamous cell carcinoma of the oropharynx (OPSCC, n = 302), oral cavity (OSCC, n = 391), or larynx (LSCC, n = 248) were involved. According to results, HIF‐1a expression was higher in OSCC than in LSCC and OPSCC. No association was found between HIF‐1a and locoregional control. High HIF‐1a expression is associated with poor outcome in OPSCC and LSCC and better outcome in OSCC.