Huvinen E, et al. - In this substudy of the RADIEL trial, a lifestyle intervention study with women at high gestational diabetes (GDM) risk, researchers assessed the impact of GDM heterogeneity on the performance of two top-rated GDM risk scores. In the high-risk cohort of 510 women, they evaluated the GDM risk score by Teede and that developed by Van Leeuwen. As per data, Van Leeuwen score estimated a 19% probability of GDM and Teede succeeded in risk identification in 61%. Predictors of GDM in the total study population were fasting plasma glucose, HbA_1c, and family history of diabetes. Among non-obese women, the lowest performance of the risk scores was seen. For detection of GDM, the marked heterogeneity of GDM is a challenge for the development of risk scores.