Kaiser J, Allaire B, Fein PM, et al. - Experts aspired to explore if the heterogeneity and spatial distribution of trabecular volumetric bone mineral density (vBMD) were correlated with prevalent vertebral fracture. In the Framingham Heart Study Multidetector CT study, they analyzed the volumetric QCT scans of the L3 vertebra in 148 candidates. Heterogeneity and spatial distributions have been contrasted between cases and controls utilizing Wilcoxon Rank Sum tests and t-tests and tested for the relationship with prevalent fractures with conditional logistic regressions independent of integral vBMD. The authors discovered that increased trabecular vBMD in the anterior compared with posterior centrum, but not trabecular vBMD heterogeneity, was linked to a reduced risk of prevalent fracture independent of integral vBMD. Regional trabecular vBMD measurements could help to determine the risk and underlying vertebral fracture mechanisms.