Tripathi R, et al. - In this study including 148 patients [30 with precancers, 98 with invasive squamous cell carcinoma (ISCC), and 20 with adenocarcinoma (ADC)] and 40 normal control participants, researchers investigated the role of hairy and enhancer of split homolog-1 (HES1) protein in human papillomavirus (HPV)-associated ADC subtype of cervical cancer (CC). They also compared its expression in histologic subtypes of precancer and ISCC via immunohistochemistry and used immunoblotting for validation of the results. Findings revealed that cervical intraepithelial neoplasia grades 2 and 3 that developed into ISCC was the source of the major HES1 positivity signal among all HPV-16–positive precancers. Moreover, an association with HES1 was also detected in HPV-16–positive ADC. They noted a synergistic role of HES1, JAG1, and Notch-3 proteins in modulating HPV associated ADC along with histologic subtypes of precancer and ISCC of CC.