Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy
Gut Oct 04, 2017
Zhou J, et al. - The role of tumour-intrinsic CDK20 or cell cycle-related kinase (CCRK) on immunosuppression in hepatocellular carcinoma (HCC) was explained. The outcomes described an immunosuppressive mechanism of the hepatoma-intrinsic CCRK signalling and highlighted an overexpressed kinase target whose inhibition could empower HCC immunotherapy.
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