Sánchez-Azofra M, Fernández I, García-Buey ML, et al. - Except in males over 55 years old, the prevalence of primary liver tumours was minimal after sustained virological response and much below the threshold for cost-effectiveness of screening in a large, well-defined cohort of patients with baseline hepatitis C stage-3 fibrosis.

• Between January-December 2015, the authors conducted a multicenter, ambispective, observational analysis of chronic hepatitis C patients who had a sustained virological response after starting therapy with direct-acting antivirals.

• Participants in the study were 506 patients (median age, 57.4 years; males, 59.9%; diabetes, 17.2%; overweight, 44.1%; genotype 3, 8.9%; HIV coinfection, 18.4%; altered liver values, 15.2%). The average period of follow-up was 33.7 (22.1-39.1) months.

• After a median of 29.4 months, five hepatocellular carcinomas and 1 cholangiocarcinoma were discovered, with an incidence of 0.47/100 patients/year.

• In the multivariate analysis, only males over the age of 55 had a significantly higher risk with an incidence of 1.1/100 patients/year.