Merchante N, et al. - The possible association between the use of direct antiviral agents (DAA) and the risk of hepatocellular carcinoma (HCC) was assessed in HIV/hepatitis C virus (HCV)-coinfected patients. HCC cases in HIV-infected patients from 32 centers from Spain were included in the GEHEP-002 cohort study. Findings revealed no increase in the frequency of HCC emergence after sustained virological response after widespread use of DAA in HIV/HCV-coinfected patients. Seemingly no impact was demonstrated by DAA on HCC recurrence in the short-term among those with previously treated HCC.