van Rosmalen BV, Furumaya A, Klompenhouwer AJ, et al. - Researchers conducted this nationwide retrospective cohort study with the aim to correlate (immuno) histopathological and molecular findings with the clinical course in the largest series of HCA in men till date. They identified a total of 66 patients from 26 centers fulfilling the inclusion criteria from the Dutch Pathology Registry (PALGA). The mean (±SD) age of the patients was 45.0±21.6 years. After expert revision and next generation sequencing (NGS), the diagnosis was changed in 33 of the 66 patients (50%). NGS led to identification of four B-catenin mutated HCA, which were not yet recognized by immunohistochemistry and expert revision. Overall findings suggest expert revision with relevant immunohistochemistry as valuable for the challenging but prognostically relevant distinction between HCA and well-differentiated HCC in male patients. NGS appears to be more relevant to subtype HCA than suggested in present guidelines.