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Hepatitis C in healthcare personnel: Follow-up analysis of treatments with direct-acting antiviral agents

Journal of Occupational Medicine and Toxicology Aug 28, 2021

Westermann C, Wendeler D, Nienhaus A, et al. - In this study population, treatment with a direct-acting antiviral agent (DAA) results in a high sustained virological response (SVR).

  • Higher SVR is linked to early viral hepatitis C (HCV) treatment.

  • The majority of the people in the study (n = 305) had HP genotype 1 infection.

  • The average age was 63 (SD 10), and 77% of the participants were female.

  • Two-thirds of the HP had fibrosis or cirrhosis and had received treatment for it.

  • Statistically, cirrhosis was shown to be much more common in men than in women.

  • It was noted that the end-of-treatment response rate was 99%, while the SVR12 and SVR24 rates were 98%.

  • Cirrhosis of the liver was found to be a statistically significant predictor of lower success rates.

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