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Hepatitis B virus screening and reactivation in a National VA Cohort of patients with inflammatory bowel disease treated with tumor necrosis factor antagonists

Digestive Diseases and Sciences May 18, 2018

Shah R, et al. - The researchers determined the adherence to the screening guidelines recommending screening for hepatitis B virus (HBV) infection prior to initiating treatment of inflammatory bowel disease (IBD) with anti-tumor necrosis factor (anti-TNF) therapy. In addition, they looked for clinical outcomes of HBV reactivation following anti-TNF use. It was a retrospective cohort study utilizing the Veterans Health Administration datasets for IBD patients with filled prescriptions for anti-TNFs from 2003 to 2011. They observed that HBV screening rates prior to anti-TNF initiation were low among IBD patients, but had increased over time. Clinically significant HBV reactivation after anti-TNF initiation in this US cohort was nonexistent despite low rates of screening.
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