Li P, Zhang D, Zhou J, et al. - Researchers sought to report the clinicopathologic features of T-cell neoplasms in liver via gathering data of 40 cases of T-cell neoplasms [29 males; median age 54 (range 2-75) years; mortality rate 83.8%] diagnosed in the liver from five large academic institutions. Among these patients, 14 (35%) were diagnosed with hepatosplenic T-cell lymphoma (HSTCL), 13 (32.5%) peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), and 13 (32.5%) other types of T-cell neoplasms. Relative to patients with PTCL-NOS and other T-cell neoplasms, those with HSTCL were much younger and had worse survival. On imaging studies, abnormalities were identified in 20 cases (50%), including 10 with mass lesions that linked with normal or cholestatic pattern enzyme elevation. Four main patterns were identified in histomorphological analysis; with the exception of mass forming lesions (pattern 4; n = 8), cases with sinusoidal predominant (pattern 1; n = 12), portal predominant with sinusoidal infiltrates (pattern 2; n = 13) or lobular aggregates (pattern 3; n = 5) exhibited small to medium lymphocytes resembling a reactive/inflammatory process. Moreover, two cases of T-cell large granular lymphocytic leukemia that resembled HSTCL, and a case of aggressive post-transplant lymphoproliferative disorder that developed following chronic EBV infection were described, indicating the relevance of EBV testing in some lymphoma cases. Overall, this study reports on the largest cohort of T-cell neoplasms in liver and yields critical data concerning disease frequency, distribution, and clinicopathologic features that are essential for accurate diagnosis.