Takemura N, et al. - In patients with portal hypertension (PH), with or without perioperative prophylactic management (PPM), researchers determined short- and long-term outcomes after hepatectomy for hepatocellular carcinoma (HCC). This retrospective study included 1,259 patients; the PPM group had 123 patients, the no-PPM group had 181 patients, and the no-PH group had 955 patients. Three- and 5-year overall survival rates in the PPM group were 74.3% and 53.1% respectively, in the no-PPM group were 69.2% and 54.9% respectively, and in the no-PH group were 78.1% and 64.2% respectively. Postoperative morbidity and mortality rates in the PPM group were 26.0% and 0.8% respectively, in the no-PPM group were 29.8% and 1.1% respectively, and in the no-PH group were 20.3% and 0% respectively. Patients with HCC who received suitable management for PH had satisfactory outcomes in an Asian population. Through use of PPM the safety of hepatic resection could be enhanced, which may help to expand the indications for hepatectomy in patients with PH.