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Hemoglobin A1c accurately predicts continuous glucose monitoring-derived average glucose in youth and young adults with cystic fibrosis

Diabetes Care Apr 26, 2018

Chan CL, et al. - The correlations among glycemic markers—HbA1c, fructosamine (FA), glycated albumin (%GA), and 1,5-anhydroglucitol (1,5-AG) and continuous glucose monitoring (CGM) were evaluated by experts in cystic fibrosis (CF). They put forth the proposition that alternate markers would better predict average sensor glucose (ASG) than HbA1c. The enrollment consisted of CF participants and a group of healthy control subjects (HC), aged 6–25 years. Findings reported that HbA1c did not underestimate ASG in CF as previously assumed. Furthermore, no alternate glycemic marker correlated more strongly with ASG than HbA1c. It was determined that %GA demonstrated a strong association with ASG and added to the prediction of ASG beyond HbA1c. The use of HbA1c for diabetes screening was not recommended in CF.
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