Xiang AH, et al. - Via a retrospective cohort study of a total of 35,819 mother-infant pairs, the observers sought to study extended previous observations by examining the association among maternal hemoglobin A_1c (HbA_1c) levels during pregnancy and risk of autism spectrum disorders (ASD) in offspring. No link between maternal Hb A_1c levels during early pregnancy and ASD in offspring when HbA_1c levels were analyzed as a continuous variable or as a categorical measure if less than 6.5%. Furthermore, a correlation with HbA_1c levels greater than 6.5% was found based on only 15 affected children. Hence, the authors observed that maternal glycemic control in early pregnancy could be important for ASD risk in offspring.