Leng X, et al. - Using a computational fluid dynamics model, researchers ascertained if hemodynamic characteristics of symptomatic intracranial atherosclerotic stenosis (sICAS) are correlated with the risk of stroke relapse. The study sample consisted of 245 patients with acute ischemic stroke attributed to 50% to 99% ICAS, which was confirmed by computed tomographic angiography. Investigators found that the risk of recurrent ischemic stroke in the same territory was significantly higher for patients with both low-pressure ratio (PR=pressure_poststenotic/pressure_prestenotic) and high wall shear stress ratio (WSSR=WSS_{stenotic − throat}/WSS_prestenotic) vs those with normal PR and WSSR. This investigation represents a step forward in the study of intracranial atherosclerotic disease through the use of computational flow simulation techniques, showing a sICAS hemodynamic pattern that is more susceptible to stroke relapse and supporting hypoperfusion and artery-to-artery embolism as common ischemic stroke mechanisms in such patients.