Prasad SB, Camuglia A, Lo A, et al. - Among patients with non-ST elevation myocardial infarction (NSTEMI), researchers tried to confirm the link between the E/e’ ratio and invasively measured left ventricular filling pressure (LVFP). They performed this study on 120 unselected patients with NSTEMI. The participants were asked to undergo cardiac catheterization with an evaluation of left ventricular end-diastolic pressure (LVEDP; elevated ≥ 15mmHg) and Doppler echocardiography with either simultaneous (n = 30) or same-day (n = 90) measurement of E/e’. The sensitivity, specificity, positive (PPV) and negative (NPV) predictive values were estimated to be 27%, 93%, 79% and 44% respectively, for the guideline-recommended threshold of average E/e’ > 14 for raised LVEDP. In this study, the E/e’ ratio was identified as a robust measure of LVFP during acute NSTEMI using upper and lower thresholds to obtain a high PPV and NPV respectively, with the use of adjunctive guideline recommend measures needed in patients with non-conclusive E/e’.