Herasevich S, et al. - In this retrospective review, researchers investigated how hemodynamic parameters in patients with sepsis and tachycardia admitted to the intensive care unit were influenced by digoxin. Participants were adult patients admitted to the medical and mixed ICU at Mayo Clinic Rochester, Minnesota from March 2008 to February 2018, started on digoxin within 24 h of ICU stay. Overall 180 patients were included. One hour prior to digoxin administration, the heart rate was 124 (115–138) beats/min; this value significantly reduced to 101 (87–117) 6 h after digoxin and 94 (84–112) 12 h after. As for median systolic blood pressure, an increase was noted; from 100 (91–112) mmHg 1 h before to 110 (100−122) and 111 (103–124) at 6 and 12 h respectively after digoxin. Findings revealed that it was uncommon that digoxin was administered early in patients with sepsis and tachycardia but improvements of hemodynamic parameters were evident in these patients in correlation with early digoxin administration.