Ger G, et al. - Given that about 50% of cases suffer an acute circulatory failure following resuscitation of cardiac arrest (CA), researchers examined if hemodynamic status and outcome of these patients could be improved via an early plasma removal of inflammatory mediators using high cut-off continuous veno-venous hemodialysis (HCO-CVVHD) in this randomized open-label trial. Thirty five patients with post-cardiac arrest shock (defined as requirement of norepinephrine or epinephrine infusion > 1 mg/h) were randomized either to receive 2 distinct sessions of HCO-CVVHD during the first 48 h following ICU admission (experimental group) or continuous veno-venous hemofiltration (CVVH) with standard membranes if needed (control group). The HCO-CVVHD group included 17 (median age 68.4, 59% male) patients while the control group included 18 (median age 66.3, 83% male) patients. Outcomes revealed no decreased length of post-resuscitation shock and no significant effect on hemodynamic profile when HCO-CVVHD provided to cardiac arrest patients.