Pitcher JH, et al. - The association of the combined effects of hypotension, hyperglycemia, dysoxia, and dyscarbia with cardiac arrest outcomes was investigated herein. Findings demonstrated an independent association of uncorrected physiological derangements in the first 24 h after cardiac arrest with poor outcome (PO). These results support preclinical models suggesting that aggressive normalization of physiology after resuscitation may be a reasonable strategy to decrease reperfusion injury.