Berg DD, Wiviott SD, Scirica BM, et al. - Using derivation and validation cohorts, researchers constructed and validatea a practical clinical risk score for hospitalization for heart failure (HHF) in patients with type 2 diabetes mellitus. Additionally, they investigated if the detection of high-risk patients with the greatest reduction in risk for HHF with a sodium-glucose cotransporter-2 inhibitor could be allowed by this score. Prior heart failure, history of atrial fibrillation, coronary artery disease, estimated glomerular filtration rate, and urine albumin-to-creatinine ratio were identified as clinical variables that independently predicted the risk of HHF. In both the derivation and validation cohorts, a > 20-fold gradient of HHF risk was detected by a simple integer-based score (0–7 points) using the abovementioned predictors, with C indices of 0.81 and 0.78, respectively. This novel clinical risk score for HHF allowed the detection of patients at higher risk for HHF who derive greater absolute benefit from sodium-glucose cotransporter-2 inhibition.