Almekhlafi MA, Goyal M, Dippel DWJ, et al. - In this meta-analysis of pooled individual patient data, researchers sought to evaluate the lifetime outcomes associated with the speed of endovascular thrombectomy in patients with acute ischemic stroke due to large-vessel occlusion (LVO). All randomized clinical trials comparing stent retriever thrombectomy devices to medical therapy in patients with anterior circulation LVO within 12 hours of their last known well time were included. Among the 781 patients who underwent endovascular thrombectomy (EVT), 406 (52.0%) were treated early [last known well/onset-to-puncture (LKWTP) ≤ 4 hours] and 375 (48.0%) were treated late (LKWTP > 4-12 hours). In this investigation, care delays were linked to a loss of healthy life-years in patients with acute ischemic stroke who were treated with EVT, especially in the post-arrival period. The discovery that every 1 second of delay resulted in a loss of 2.2 hours of healthy life may encourage continuous quality improvement in door-to-treatment times.