Spertus JA, Jones PG, Maron DJ, et al. - Given no decrease in clinical events was afforded by an invasive strategy with angiographic evaluation and revascularization in patients with stable ischemic heart disease and moderate or severe ischemia in the ISCHEMIA trial, and a secondary goal of the trial was to evaluate angina-associated health status in these patients. Researchers evaluated angina-associated symptoms, function, as well as quality of life using the Seattle Angina Questionnaire at randomization, at months 1.5, 3, and 6, and every 6 months thereafter among patients who had been randomized to an invasive treatment strategy (2,295 participants) or a conservative strategy (2,322). Greater improvement in angina-associated health status was evident in patients randomly allocated to the invasive strategy vs those assigned to the conservative strategy in the overall trial sample with moderate or severe ischemia, which incorporated 35% of participants without angina at baseline. Among asymptomatic patients and among those who had had angina at baseline, minimal differences and larger differences, respectively, were reflected by the modest mean variations favoring the invasive strategy in the overall group.