Tohme S, Sanin GD, Patel V, et al. - Researchers sought for factors that are predictive of health-related quality of life (HRQoL), the change in HRQoL over time, and HRQoL prognostic value in patients undergoing surgical resection of hepatic malignancies. One hundred twenty-eight patients with primary and metastatic hepatic malignancies (mean age: 61 y; 42.6% with hepatocellular carcinoma, and 50.7% with metastatic colorectal carcinoma) enrolled between January 2008 to November 2011 and November 2013 to June 2015 were administered the Functional Assessment of Cancer Therapy–Hepatobiliary, Center for Epidemiologic Studies-Depression, Functional Assessment of Cancer Therapy–Fatigue, and Brief Pain Inventory. The analysis revealed the independent correlation of HRQoL with survival in patients with liver malignancies undergoing surgical resection. In patients with cancer, major curative liver surgery can be offered with short-term worsening of HRQoL but long-term improvement and stabilization in overall quality of life.