Thompson K, et al. - Researchers performed a primary propensity score matched analysis of patients with and without sepsis enrolled in a large multicentre clinical trial, to investigate the differences in health-related quality of life (HRQoL), survival and healthcare resource use of both groups of patients. Linked data collection for 3442 (97.3%) of 3537 eligible patients was done, followed by matching 806/905 (89.0%) patients with sepsis with 806/2537 (31.7%) without. Findings reported higher healthcare resource use and costs for critically ill patients with sepsis when compared with matched patients without sepsis. In addition, those with sepsis had similar survival and HRQoL relative to those without sepsis.