Russo GT, et al. – Taking into account a large series of patients and an important follow–up period, atherogenic dyslipidemia as well as subtle modifications in lipoprotein particles profile are associated with incidence and progression of microvascular disease in type 2 Diabetes (T2D) women.

Methods

• The physicians present the data on the effect of diabetic dyslipidaemia, the HDL subclasses distribution and the common cholesteryl ester transfer protein (CETP)TaqIB variant on the incidence or the progression of diabetic kidney disease (DKD) and diabetic retinopathy (DR) in 97 T2D women, after a ~9 years of follow–up.

Results

• It was noted that T2D women presented with low HDL–C levels and higher levels of large lipid rich α–1 (16.34 mg/dl), α–2 (33.39mg/dl) and pre– α1 (4.81 mg/dl) HDL subparticles at baseline.
• The obtained data indicate that the CETP TaqIB polymorphism and baseline HbA1c, triglycerides, and HDL–C levels as well as specific HDL subpopulations were associated to the occurrence of RD after ~9 years of follow–up.
• The outcomes indicated HbA1c, triglycerides and the less atheroprotective α–3 HDL particles were the only factors independently associated to the incidence of RD.
• These same variables were also correlated with the progression from background to proliferative RD.
• According to the data, BMI, LDL/HDL ratio and low levels of α–1 HDL particles were correlated to the occurrence of DKD at univariate analysis, while BMI was the only significant predictor at stepwise multivariate regression analysis.