Brinck JW, et al. - As a part of this study, authors comparatively analyzed the plasma levels of sphingosine-1-phosphate (S1P), high-density lipoprotein (HDL)-associated S1P (HDL-S1P) and HDL-mediated protection against oxidative stress between chronic kidney disease (CKD) and control patients. Uremic HDL was discovered to be more effective than control HDL for safeguarding the cardiomyocytes against oxidative stress. This data was elucidated through its higher S1P content which previously appeared to be the determinant of HDL-mediated cardioprotective capacity. It was perceived that lower concentrations of albumin in CKD were related to higher HDL-S1P.