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HBsAg-negative and anti-HBc-positive in eosinophilic granulomatosis with polyangiitis: A retrospective pilot study

Rheumatology International May 26, 2018

Lee SW, et al. - Experts evaluated if resolved hepatitis B virus (HBV) infection was related to antineutrophil cytoplasmic antibody-associated vasculitis (AAV), and affected AAV activity at diagnosis and prognosis during the follow-up. Findings suggested a significantly increased risk of relapse of eosinophilic granulomatosis with polyangiitis (EGPA) in patients having anti-HBc than those who did not have it. Moreover, meaningfully lower cumulative relapse-free survival rates were seen in EGPA patients with HBs-negative/anti-HBc-positive vs those without during the follow-up duration. Vasculitis activity could be importantly influenced by resolved HBV infection at diagnosis and subsequently relapse after remission in EGPA patients.
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